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Author

Francesco Saverio Ragusa

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Review Open access Sep 2026

The Impact of Metabolic and Bariatric Surgery on Nutritional Status and Sarcopenia: A Narrative Overview of Underlying Mechanisms, Clinical Implications, and Prevention Strategies

Bariatric surgery is the most effective treatment for severe obesity, leading to significant and sustained weight loss and improvement in metabolic comorbidities. However, it is also associated with substantial changes in body composition and nutritional status, including the risk of sarcopenia and sarcopenic obesity. This review aims to summarize current evidence on the interplay between metabolic and bariatric surgery, nutritional alterations, and skeletal muscle health. The recent literature highlights a high and increasing prevalence of muscle loss after surgery, driven by reduced protein intake, micronutrient deficiencies, hormonal changes, and decreased mechanical loading. Despite these challenges, improvements in metabolic health and physical function are often observed, suggesting a complex relationship between muscle mass and functional outcomes. A multidisciplinary approach, including nutritional optimization and structured exercise interventions, is essential to mitigate muscle loss and function and improve long-term outcomes. Further research is needed to standardize diagnostic criteria and develop targeted strategies for prevention and management.

Ligia J. Dominguez, F. S. Ragusa, N. Veronese et al. · 0 citations
Review Open access Aug 2026

The prognostic value of frailty criteria in older adults: a systematic review and meta-analysis

Frailty components, especially weakness and slowness, are significantly associated with mortality and related outcomes, highlighting the urgency of early frailty detection to improve patient prognosis and urging early identification and intervention to enhance patient care and reduce clinical burden.

K. Prokopidis, Francesco Saverio Ragusa, Roberta Bonica et al. · 0 citations

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