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Author

F. Rommasi

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Open access Sep 2026

Transcription pause and elongation regulators mediate somatic hypermutation

Somatic hypermutation (SHM) creates point mutations in immunoglobulin (Ig) gene variable (V) regions in activated B cells to support antibody affinity maturation1. SHM is initiated by activation induced deaminase (AID), a cytosine deaminase whose single-stranded DNA (ssDNA) substrate is thought to arise during RNA Poly...

Li-Zhen Wu, A. D. Yadavalli, Caillan C. McAuliffe et al. · 1 citation
Open access Aug 2026

Deciphering Novel Transcriptional Wiring in Colorectal Cancer: An Integrative Bioinformatic and Experimental Study

Experimental results showed melatonin reduces SW480 viability with an IC₅₀ of 2.63 mM and lowers BUB1 and CCNA2 expression in different manners of concentration-dependency, while NCAPG remains unchanged, and selective repression of two NF-Y targets with sparing of a non-target is consistent with reduced NF-Y-dependent...

F. Rommasi, B. Dabirmanesh, Khosrow Khajeh · 0 citations

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