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Author

F. Puglisi

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Open access Sep 2026

DPYD c.85T>C, DPYD c.496A>G, and DPYD c.2194G>A and severe toxicity to fluoropyrimidines in PREPARE and Alpe-DPD trials. An original study and meta-analysis.

Current DPYD genotyping panels used to prevent fluoropyrimidine (FL)-related toxicity explain only a limited proportion of severe adverse events. The clinical relevance, beyond current testing, of additional DPYD variants, including DPYD⁎6 (c.2194G>A, rs1801160), DPYD c.496A>G (rs2297595), and DPYD⁎9A (c.85T>C, rs18012...

E. De Mattia, J. Polesel, M. van der Lee et al. · 0 citations
Open access Oct 2026

Age-specific patterns in colorectal cancer incidence and survival over time: a 17-year population-based cancer registry study from northeastern Italy.

Findings support timely diagnosis and appropriate care across age groups, continued screening among eligible individuals, and dynamic prognostic assessment in colorectal cancer.

M. Taborelli, F. Toffolutti, T. Angelin et al. · 0 citations
Open access Sep 2026

CDK12/13 inhibition overcomes platinum resistance by impairing RNA metabolism

Epithelial ovarian cancer (EOC) is a highly lethal disease characterized by a high rate of platinum (PT)-resistant recurrence. Dysregulation of transcriptional and alternative splicing (AS) has been suggested as a possible mechanism of PT resistance involving transcriptional cyclin-dependent kinases (CDKs). We report t...

Ilenia Pellarin, Valentina Rossi, R. Margiotta et al. · 0 citations
Open access Aug 2026

Ten-year survival of women with invasive breast cancer by stage, molecular subtype, and grade combined: a population-based study

Abstract Background Stage at diagnosis, histologic grade, and molecular subtypes are established prognostic indicators for women with breast cancer (BC), but their impact on population-based survival estimates is poorly documented. This study assessed long-term BC survival trends according to these factors. Methods We...

Fabiola Giudici, D. Serraino, F. Puglisi et al. · 0 citations
Review Open access Jul 2026

Unraveling the use of vaccine therapy in HER-2 positive breast cancer: a comprehensive review of current state and future perspectives

While advanced-stage BC often presents an immunosuppressive tumor microenvironment that hinders vaccine efficacy, early-stage disease offers a more favorable immunological milieu for inducing robust and durable T-cell responses.

A. Caltavituro, C. Martinelli, M. Palleschi et al. · 0 citations

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