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Childhood exposure to PPAU is associated with an increased risk of anxiety and depression in adulthood, and the available evidence suggests that these associations may be partly explained by co-occurring childhood adversities and broader family dysfunction.
Overall, long-term stimulant treatment was consistently associated with improvements in executive functioning, attention, emotional regulation, inhibitory control, social and occupational functioning, and quality of life, although findings regarding working memory and broader cognitive enhancement were mixed.
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