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Impact of brain and blood iron on glial density in aging, and relations to cognition: evidence from a 5-year longitudinal multimodal MRI-PET study.
It is suggested that higher local subcortical iron accumulation contributes to low-grade neuroinflammation in middle-aged and older adults, but only brain iron accounts for cognitive and motor decline, indicating that low-grade neuroinflammation may partly constitute an adaptive response to the deleterious effects of i...