F. Mallamaci

Aldosterone and Residual Cardiorenal Risk: Pathophysiology and Emerging Therapeutic Strategies.

Aldosterone, the terminal effector of the renin-angiotensin-aldosterone system, regulates sodium retention, potassium excretion, and blood pressure. Beyond these classical effects, aldosterone-associated and mineralocorticoid receptor (MR)-mediated signaling is implicated in inflammation, oxidative stress, fibrosis, al...

Heart failure in chronic kidney disease: what the second universal definition changes.

Effects of Sodium-Glucose Cotransporter-2 Inhibitors on Inflammatory Biomarkers: A Systematic Review and Meta-Analysis.

BACKGROUND AND AIMS Sodium-glucose cotransporter-2 inhibitors (SGLT2is) improve cardiovascular and kidney outcomes, but their effects on circulating inflammatory biomarkers remain uncertain. We systematically reviewed randomized evidence on the effects of SGLT2is on peripheral-blood inflammatory biomarkers. METHODS P...

Beyond Kt/V: Redefining Dialysis Adequacy as Targeted Cardiovascular Risk Reduction.

BACKGROUND Cardiovascular disease remains the leading cause of death in patients receiving maintenance dialysis, whereas conventional thrice-weekly hemodialysis was developed primarily around small-solute clearance rather than cardiovascular protection. AIM This narrative review examines dialysis strategies intended...

Personalizing cardiovascular prevention in chronic kidney disease: an operational framework for risk-treatment mapping.

Patients with chronic kidney disease (CKD) bear a disproportionate burden of cardiovascular (CV) morbidity and mortality, yet preventive strategies in clinical practice remain remarkably conservative and largely therapy-centered. The 2024 KDIGO guideline on CKD evaluation and management advocates the systematic use of...

The nephrologist in the present and near future: between algorithms and autonomy.

Overall, AI can support proactive, person-centred kidney care only if clinicians help design, govern, evaluate, and critically supervise these emerging technologies within robust, learning healthcare systems.