Melatonin ameliorates NEC-associated brain injury by suppressing pro-inflammatory (M1-like) microglia via the AMPK-IL-1β axis.
BACKGROUND Necrotizing enterocolitis (NEC) is a severe neonatal gastrointestinal disease. Its associated brain injury involves neuroinflammation and long-term cognitive impairment, yet specific therapies are lacking. Melatonin (MEL) has shown neuroprotective effects, but its role in NEC-associated brain injury remains...