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Open access Sep 2026

Melatonin ameliorates NEC-associated brain injury by suppressing pro-inflammatory (M1-like) microglia via the AMPK-IL-1β axis.

BACKGROUND Necrotizing enterocolitis (NEC) is a severe neonatal gastrointestinal disease. Its associated brain injury involves neuroinflammation and long-term cognitive impairment, yet specific therapies are lacking. Melatonin (MEL) has shown neuroprotective effects, but its role in NEC-associated brain injury remains...

Yi-Jia Wang, Bao-Zhu Chen, Xing-Xue Deng et al. · 0 citations

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