Author

F. M. de Oliveira

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Open access Jul 2026

Dysregulation of the miR-34a/SIRT1 Regulatory Network Is Associated with Cardiometabolic Risk in Type 2 Diabetes

Cardiometabolic risk in T2DM is associated with a coordinated molecular signature characterized by miR-34a upregulation, SIRT1 suppression, systemic inflammation, oxidative stress, and endothelial dysfunction, suggesting that integrated biomarker profiling may complement conventional risk assessment and support future...

F. M. de Oliveira, F. S. Lizarte, E. V. Fernandes et al. · International Journal of Tra... · 0 citations

Jul 2026

Epigenetic Remodeling Through GSK343-induced EZH2 Inhibition Alters SMYD2/SMYD3 Expression and Promotes Antitumor Effects.

These findings demonstrate that EZH2 inhibition promotes coordinated epigenetic remodeling and disrupts key oncogenic pathways in breast cancer cells, and suggest potential combinatorial strategies integrating EZH2 inhibition with other targeted or epigenetic therapies to enhance treatment efficacy, overcome resistance...

Thaís Amanda Damasceno Silva, E. V. Fernandes, Mayara Bocchi et al. · Clinical Breast Cancer · 0 citations