The integration of assistive technologies (AT) in the intervention for children with Autism Spectrum Disorder (ASD) is critical. However, the mechanisms through which professional training translates into practical competence remain under-explored. This study examines a moderated mediation model to understand how academic domain and educational expectations influence this transition.
A cross-sectional study was conducted with 227 students (97.4% female, ages 18-45) from the University of Bucharest, specializing in Special Psychopedagogy (48%), Pedagogy (25.1%), and Primary/Preschool Education (26.9%). Participants completed assessments regarding their preparation/training, perceived educational needs/expectations, and practical experience in AT. Data were analyzed using moderated mediation analysis (Delta method) to assess conditional direct and indirect effects.
Moderated mediation analysis revealed that all interaction paths were significant (
p
< .05). A key finding was the “filter effect” of educational expectations: as student needs increased, the conditional indirect effect of training on practice significantly strengthened (
β
Low = 0.230,
p
= .020;
β
High = 0.511,
p
< .001). Conversely, the conditional direct impact of training on practice weakened as expectations rose (
β
Low = 1.395,
p
< .001;
β
High = 0.805,
p
< .001). Notably, while 70.5% of students reported below-average formal training, 100% demonstrated above-average practical application, indicating a heavy reliance on subjective expectations and domain-specific context.
Professional training in AT does not produce uniform outcomes. Its efficacy is maximized when calibrated to the specific academic domain and the individual motivational structure of the students. For clinical and educational practice, these findings suggest that “one-size-fits-all” training programs are suboptimal. To effectively translate theoretical knowledge into high-quality interventions for children with ASD, programs must integrate students’ subjective expectations and the unique requirements of their specialization.
F. Lincă, Elena Marin· Frontiers in Education· 0 citations
Genetic neurodevelopmental disorders (NDDs) encompass a heterogeneous group of conditions characterized by impaired cognitive, behavioral, and neurological development resulting from pathogenic variants affecting brain development and synaptic function. Advances in molecular genetics and next-generation sequencing have significantly expanded the understanding of the genetic architecture underlying disorders such as Rett syndrome (RTT), Fragile X syndrome (FXS), Angelman syndrome (AS), and autism spectrum disorders. Beyond these classical neurodevelopmental disorders, spinal muscular atrophy (SMA) is included as a paradigmatic example of successful RNA-based therapeutic translation. Concurrently, RNA-based therapeutics have emerged as promising precision medicine strategies capable of modulating gene expression at the transcriptional and post-transcriptional levels. These approaches include antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), messenger RNA (mRNA) therapies, RNA editing technologies, and splice-modulating agents. Recent clinical successes, particularly in spinal muscular atrophy, have demonstrated the transformative potential of RNA therapeutics in neurological disease. However, substantial challenges remain, including BBB penetration, long-term safety, immune activation, and genotype-specific variability in therapeutic response. This review summarizes current advances in RNA-based therapeutics for genetic NDDs, highlighting molecular mechanisms, disease-specific therapeutic strategies, translational progress, delivery challenges, and future directions. Overall, continued progress will depend on the integration of disease biology, rational RNA therapeutic design, and effective CNS-targeted delivery, supporting the broader implementation of precision RNA medicine for genetic neurodevelopmental disorders.
I. Focșa, C. Iliescu, C. Pomeran et al.· International Journal of Mol...· 0 citations
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