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F. Fraternali

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Open access

B-Cell Aware Analysis of Single-Cell Transcriptomics Data.

A protocol is presented that analyses scRNA-seq alignments and count matrices, as well as B-cell receptor sequencing data obtained in parallel to scRNA-seq, and provides practical guidance on how CSR and SHM information can be extracted from the data and utilized to build robust computational models of B-cell maturatio...

Joseph C. F. Ng, R. Ruiz-Hernandez, I. Withnell et al. · 0 citations
Open access Aug 2026

Tumor-infiltrating B cells evolve towards interferon-rich trajectories aligned with immunotherapy in melanoma

Melanoma-infiltrating B cells follow class-switched differentiation trajectories culminating in IFN signaling, atypical antibody expressing states that persist or emerge after immunotherapy, aligning dynamic B cell evolution and atypical lineage traits with immunotherapy.

K. Stoker, R. Laddach, Lucy Booth et al. · 0 citations

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