Author

F. Dotta

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#protein folding Open access Oct 2026

Non-electrophilic TRPA1 modulator MNP-021 protects neuronal and glial function from diabetes-associated glucotoxicity and neuroinflammation

In a sustained high-glucose model, MNP-021 reduced the high-glucose-associated increase in cell death, extending its protective effects beyond the acute MGO paradigm, and support further preclinical evaluation of MNP-021 in dicarbonyl-linked neuro-metabolic stress.

Alessandro De Carli, Carolina Filipponi, Beatrice Polini et al. · Journal of Translational Med... · 0 citations

Open access Sep 2026

Small RNA profiling reveals inflammatory and mitochondrial changes in aging β cells and islet macrophages

Aging is associated with functional decline and senescence of pancreatic β-cells. Modulation of post-transcriptional mechanisms is a hallmark of aging. Here we analyze the small non-coding RNA (sncRNA) repertoire of FACS-sorted β-cells and islet-resident macrophages (iMACs) from 3-, 12-, and 22-month-old mice, and of...

C. Guay, Jérôme Perrard, Eleonora Mangano et al. · Communications Biology · 0 citations

Open access Aug 2026

Twenty-four-month evaluation of the glycemia risk index in adults with type 1 diabetes using advanced hybrid closed-loop systems

It is suggested that GRI may serve as a useful, readily interpretable metric for predicting long-term glycemic outcomes and support its complementary role alongside TITR in clinical assessment.

L. Nigi, Leonardo Di Stefano, G. Grieco et al. · Endocrine · 0 citations