Author

F. Di Domenico

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Review Open access Oct 2026

O-linked β-N-acetylglucosamine homeostasis in brain health and disease: From physiology to neurodevelopmental and neurodegenerative disorders.

ABSTRACT Protein O-GlcNAcylation is a dynamic and reversible post-translational modification that functions as a central nutrient-sensing mechanism linking cellular metabolism to protein function. Controlled by the opposing activities of O-linked β-N-acetylglucosamine transferase and O-GlcNAcase, O-GlcNAcylation regula...

F. Di Domenico, Laiba Ashraf, Chad Slawson et al. · Neural Regeneration Research · 0 citations

Open access Sep 2026

Biliverdin reductase A deficiency reveals sex- and brain region-specific vulnerability to high-fat diet feeding

How the brain senses and responds to early metabolic stress, and why this process fails differently across sexes and regions, remains poorly understood. Here we show that biliverdin reductase A (BVRA) loss is associated with sex- and brain region-specific effects in response to high-fat diet (HFD) feeding, impairing in...

Simona Lanzillotta, V. Sommella, Barbara Zulli et al. · Redox Biology · 0 citations