Author

F. De Smet

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Aug 2025

O-mannosylation and protein maturation check-points represent therapeutic opportunities in BRAF fusion protein oncogenesis

Fusions between protein-coding genes are common oncogenic drivers across cancers, typically pairing a proto-oncogene with partner that does not independently drive cancer. In all therapeutically actionable fusions, the proto-oncogene is the drug target, the contributions to oncogenicity of the fusion partner have large...

Anna Borgenvik, Sean A. Misek, Daniel Christen et al. · bioRxiv · 1 citation

Open access Sep 2026

Heterogeneous and conserved radiation responses reveal FOXM1-dependent regulation of microcephaly genes in glioblastoma

Findings identify coordinated suppression of a FOXM1-associated MCPH program as part of the GBM radiation response, while suggesting that the radiosensitizing effects of pharmacological FOXM1inhibition extend beyond this transcriptional axis.

L. Van Eupen, E. Etlioglu, K. Tabury et al. · bioRxiv · 0 citations

Open access Aug 2026

Unravelling resistance mechanisms of oncolytic viruses in glioblastoma

These findings reveal shared and virus-specific cellular processes driving OV resistance in GBM, providing a basis for strategies to overcome resistance.

T. Deconinck, T. Dierckx, F. De Smet et al. · bioRxiv · 0 citations

Open access Aug 2026

A compendium of next-generation patient-derived models for diverse cancers

A large-scale international programme—the Human Cancer Models Initiative—is presented, which involved the generation of a resource of 665 next-generation models from 2,780 donors with 25 cancer types and integrated tumour–model whole genome, exome, methylome and transcriptome analyses.

Dina Elharouni, Mushriq Al-Jazrawe, Seongmin Choi et al. · Nature · 7 citations