Author

F. Chiaradonna

2 papers indexed here

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Open access Aug 2026

FECH, a novel metabolic target influencing CAR T-cell phenotype and function

Recent phase I/II clinical trials have demonstrated that chimeric antigen receptor (CAR) T cells targeting the disialogangliosade GD2 represent a promising therapeutic option for pediatric patients with relapsed or refractory high-risk neuroblastoma (NB). However, incomplete and heterogeneous clinical responses highlig...

Marsha Pellegrino, Simone Vespa, I. Salvatori et al. · Biomarker Research · 0 citations

Open access Sep 2026

PGM3 inhibition rewires RUVBL2-dependent DNA repair and induces a BRCAness-like state in pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC) exhibits profound metabolic rewiring and strong resistance to DNA-damaging therapies, yet how metabolic pathways regulate genome maintenance remains poorly understood. The hexosamine biosynthetic pathway (HBP) integrates nutrient availability with protein glycosylation through pr...

Barbara Zerbato, Gabriele Taverna, Marina La Chimia et al. · bioRxiv · 0 citations