Author

F. Cavallo

2 papers indexed here

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Review Open access Oct 2026

The Osteosarcoma Tumor Microenvironment: Supportive of Tumor Progression, Hostile to Immunity, but Therapeutically Targetable

Osteosarcoma (OSA) remains the most common primary malignant bone tumor of children and young adults, with limited survival improvements in patients with relapsed or metastatic disease despite multimodal chemotherapeutic treatment. Beyond the intrinsic heterogeneity and malignancy of tumor cells, OSA progression and th...

L. Tarone, I. Merighi, E. Tirtei et al. · Cancers · 0 citations

Review Open access Sep 2026

STING-mediated tumor microenvironment remodeling: turning adaptive resistance into therapeutic vulnerability

It is proposed that rational combinations of STING agonists with Fc-engineered PD-L1/PD-L2-targeting antibodies, guided by dynamic and spatial biomarkers, could overcome resistance to conventional immune checkpoint blockade in tumors with minimal T-cell infiltration but targetable tumor vasculature.

Akash R. Boda, E. Bolli, A. Salameh et al. · Frontiers in Immunology · 0 citations