Structure Activity Relationship of 4-((2-hydroxybenzylidene) amino) benzoic acid and 4-((4 methoxybenzylidene) amino) benzoic acid as Potential Larvicidal Agents against Aedes aegypti Larvae
The widespread application of conventional synthetic pesticides has raised major environmental issues because of their persistence, bioaccumulation, and biomagnification. The urgent need to address these risks calls for the development of more eco-friendly alternatives in pest management. Consequently, the objective of this paper was to investigate the structure activity relationship of 4-((2-hydroxybenzylidene) amino) benzoic acid [A1] and 4-((4 methoxybenzylidene) amino) benzoic acid [A2] as potential larvicidal agents against Aedes aegypti larvae using appropriate standard procedures. Data obtained reveals that percentage mortality was determined using Abbott's formula. Both compounds demonstrated larvicidal activity in a dose-dependent manner. At 2.5 mg/mL, the Schiff bases achieved 95.5 and 99 % mortality for A1 and A2 respectively. At lower concentrations of 0.5 mg/ml, the ligands showed slightly high activity. These findings indicate that these Schiff bases have promising larvicidal activity, suggesting their potential as safer and more environmentally friendly pest management alternatives. The results highlight the possibility of these compounds supporting environmental biodiversity.