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Oct 2026

"Interstitial lung disease with associated severe pulmonary hypertension is rarely idiopathic by clinical or pathologic measures".

BACKGROUND Interstitial lung disease (ILD) patients who develop severe pulmonary hypertension (PH) have rapidly progressive disease and increased mortality, but their clinical and pathologic phenotypes are poorly defined. Improved understanding and identification of these patients will expedite beneficial PH-targeted t...

A. Brownstein, F. Shaikh, Guang-Qian Xiao et al. · 0 citations
Open access Oct 2026

A CCL21 gene-modified dendritic cell vaccine combined with pembrolizumab in advanced non-small cell lung cancer: a phase I trial

Immune checkpoint inhibitors (ICIs) have transformed treatment for non-small cell lung cancer (NSCLC), but resistance to these therapies is common. We report here results from a phase I trial combining intratumoral injection of a CCL21-expressing dendritic cell (CCL21-DC) vaccine with pembrolizumab in patients with...

M. Oh, A. Lisberg, C. Dumitras et al. · 0 citations

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