Author

Ezequiel A. Galpern

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Open access Aug 2026

Blending physics-based and inverse folding models to disentangle variant effects on stability and function

It is shown that blending IF models with a physics-based coarse-grained potential improves global correlation with experimental ΔΔG and, crucially, reduces IF model bias at functional sites, and is found that disease gain-of-function variants show a distinct functional signature from loss-of-function variants.

Ezequiel A. Galpern, Xavier Soler Sanchis, Charles W. J. Pugh et al. · bioRxiv · 0 citations

#protein folding Review Aug 2026

Dark energy: the cost of function in protein evolution

This work reviews the computational and experimental approaches that disentangle folding and function at scale, revealing a dark energy component and providing new insights into how biological information flows from sequence to structure to function and back to sequence.

Ezequiel A. Galpern, Federico Caamaño, Ignacio E. Sánchez et al. · 0 citations