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Author

Evgenia A. Elizarova

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Open access Sep 2026

A Unified 3D Generative Model for Synthesizable Structure-Based Drug Design

LDDM (Large Drug Discovery Model) is introduced, a generative framework that supports a range of drug discovery tasks, including constrained and unconstrained docking, fragment linking and growing, and de novo design, and a programmable design algorithm that enables accurate design of synthetically accessible compounds...

Ilia Igashov, Arne Schneuing, Adrian W. Dobbelstein et al. · 0 citations
Open access Jul 2026

The Human Bindome: A Proteome-scale Atlas of Designed Binder Candidates

The Human Bindome is presented, a proteome-scale atlas of high-confidence in silico protein binder candidates that positions the Bindome as a resource of genetically encodable perturbagens for site-specific, modular control of protein function.

Julius Wenckstern, Anna M. Díaz-Rovira, Julia A. Kuhn et al. · 0 citations

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