α-Actinin is an actin-crosslinking protein that influences cytoskeletal organization by forming actin bundles or networks. Divalent cations, such as magnesium cations (Mg2+), promote bundling through counterion condensation. While α-actinin and Mg2+ individually promote actin bundle assembly, their combined effects on...
Jinho Park, Ramsha Hashmi, Eunyoung Moon et al.· Cytoskeleton· 0 citations
Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by hepatic steatosis, metabolic stress, and inflammation. Although free fatty acid (FFA)-based in vitro models are widely used, how OA:PA ratios shape hepatocellular phenotypes remains incompletely characterized. HepG2 cells were treated with olei...
H. Jeong, Yesol Han, Jiyeong Park et al.· Cells· 0 citations
A genetically controlled in vivo model of LBD-like mixed proteinopathy recapitulating αSyn aggregation, tau hyperphosphorylation, Aβ accumulation, neurodegeneration, and behavioral decline is established and supports a mechanistic link between AIMP2-enhanced αSyn toxicity and secondary proteinopathies.
Doeun Kim, Hee-Tae Kim, Ji Hun Kim et al.· Cell Death & Disease· 0 citations
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