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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Eunha Kim

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Open access Sep 2026

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

A synthetic ionizable lipid with a dual pKa property that is retained in formulated LNPs is introduced and it is shown that after intravenous injection, these dual pKa LNPs produce lung‐selective mRNA expression with higher potency than a cationic lipid‐rich comparator while remaining well tolerated.

Seong Gi Lim, Min-Ju Lee, Yiming Wang et al. · 0 citations

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