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Eun-Sol Choi

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Open access Oct 2026

Identification of small-molecule inhibitors of the immune system repressor Regnase-1

Regnase-1 is an essential RNase that suppresses immune cell activation by targeting the mRNA of pro-inflammatory cytokines such as interleukin 6 (IL-6). Although genetic inhibition of Regnase-1 activity in CD8+ T cells has been shown to enhance antitumor immunity, no molecular inhibitors of Regnase-1 have been report...

Arthur Millius, C. Yew, Yuko Misumi et al. · 0 citations

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