Transdermal Delivery of an Adjuvanted SARS-CoV-2 Triple RBD Subunit Vaccine in Mice Using Dissolving Microneedle Array Patch
Background: The continuous emergence of antigenically distinct SARS-CoV-2 variants of concern (VOCs) necessitates the development of versatile and effective vaccine platforms capable of inducing broad and sustained immunity. Methods: We designed a chimeric trivalent recombinant protein, TriRBD, incorporating the recept...