Interleukin (IL)-31 is a pruritogenic cytokine implicated in atopic dermatitis (AD), but its transcriptional regulation in epidermal keratinocytes remains unclear. We investigated whether early growth response 1 (EGR1) links Toll-like receptor (TLR)1/2 signaling to IL31 expression through nuclear IL-33 and signal trans...
Euitaek Jung, Ye-Na Choi, Junekyu Han et al.· Biochemical and Biophysical...· 0 citations
Findings establish EGR1-dependent regulation of CCL2 in inflammatory keratinocytes and support further investigation of EGR1 DNA-binding activity as a pharmacological target in cutaneous inflammation.
Ye-Na Choi, Euitaek Jung, Junekyu Han et al.· International Journal of Mol...· 0 citations
This study identifies d4 as a promising lead compound that targets ERK-mediated signaling in HCC827 NSCLC cells and highlights the therapeutic potential of the (Z)-2-benzylidenebenzofuran-3(2H)-one structure in inhibiting hyperactivated MAPK signaling.
Junekyu Han, Seunghyun Ahn, Euitaek Jung et al.· Anti-Cancer Agents in Medici...· 0 citations
Findings establish HBP-10 as a highly promising anticancer hit compound for the development of next-generation therapeutic agents, targeting ROS-mediated cellular stress in EGFR-mutant NSCLC.
Jiseong Baek, Seunghyun Ahn, Heewon Kang et al.· Bioorganic & Medicinal Chemi...· 0 citations
Epigenetic reprogramming accompanies the transition to an osimertinib-tolerant state in EGFR-mutant HCC827 cells, and targeting HDACs and sirtuins may represent a promising strategy to eliminate DTP subpopulations and delay or prevent acquired resistance.
