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Although pancreatic ductal adenocarcinoma (PDAC) has long been considered immunologically "cold," recent studies have revealed complexity in how neoantigen quality, T cell composition, and spatial immune organization influence patient outcomes and responsiveness to emerging immune-based therapies. However, these...
Pancreatic ductal adenocarcinoma (PDAC) disease progression involves complex cell state transitions in both malignant and non-malignant populations within the tumor microenvironment. To uncover PDAC cell states and epigenetic features associated with clinical outcome, we profiled 40 tumor samples (33 primary tumors a...
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