Open access
Jul 2026
Comparative evaluation of reference-free transcriptomic deconvolution highlights the importance of biological validation in astrocytes across Alzheimer’s disease
A comparative framework evaluating two complementary unsupervised approaches, CDSeq and DECODER, to reconstruct astrocyte-associated transcriptomic profiles from human hippocampal samples spanning control, mild cognitive impairment, and AD stages establishes a reproducible strategy for evaluating deconvolution methods and their functional consequences.
Laura Rodríguez-Millan, Andrea Angarita-Rodríguez, Viviana Vargas-López et al.
· Frontiers in Bioinformatics · 0 citations