Author

Essa M. Saied

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#protein folding Open access Oct 2026

Development of 7-hydroxy-4-methylcoumarin–cyanoacrylate hybrids with antiproliferative activity against breast cancer cells: from molecular design to in vivo validation

Findings identify compound 8 as a promising antiproliferative and antitumor lead and support further optimization and evaluation of this scaffold in more clinically relevant breast cancer models.

Manar A. El-Zend, I. M. El-Deen, Zeinab Abdelkarim et al. · RSC Advances · 0 citations

Aug 2026

Metabolomics-guided network pharmacology and molecular modeling suggest bioactive components of Chiliadenus montanus associated with multi-target anticancer and anti-inflammatory activities

Overall, CME activity is associated with modulation of apoptotic and inflammatory signaling pathways, supported by biochemical, cellular, metabolomic, and computational analyses.

Ghazi A. Bamagous, H. Almasmoum, Mazen M. Ghaith et al. · Medical Oncology · 0 citations

#protein folding Open access Aug 2026

Quinoxaline-based cyanoacrylate hybrids as multi-target anti-proliferative and anti-inflammatory agents with potent activity against hepatocellular carcinoma: induction of apoptosis and modulation of oxidative stress signaling

Findings identify compound 9 as a promising multi-target quinoxaline-based agent with dual antiproliferative and anti-inflammatory activities, mediated through induction of mitochondrial apoptosis and modulation of oxidative stress and cytokine signaling pathways.

S. Alshawwa, Ghazi A. Bamagous, Hatem A. Sembawa et al. · RSC Advances · 0 citations