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Author

Esmeralda García-Rodríguez

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Open access Sep 2026

ALPHA-1 antitrypsin genotype, sex, and lung cancer: Clinical and molecular characterisation.

INTRODUCTION AND OBJECTIVES Alpha-1 antitrypsin deficiency is associated with lung and liver disease, but its role in lung carcinogenesis remains unclear. This study aimed to compare the clinical, functional, and molecular characteristics of lung cancer according to alpha-1 antitrypsin (AAT) genotype and, additionally,...

Esmeralda García-Rodríguez, R. Tubío-Pérez, Cristina Candal-Pereira et al. · 1 citation
Open access Oct 2026

Common alpha-1 antitrypsin deficiency genotypes: lung cancer risk and tumour molecular profile

Carriage of common AAT-deficient alleles was inversely associated with LC after adjustment for major confounding factors, and the association with higher PD-L1 expression suggests that these common AAT-deficient genotypes may be associated with differences in tumour phenotype rather than acting as a direct aetiological...

Esmeralda García-Rodríguez, Alberto Ruano Raviña, C. Candal-Pedreira et al. · 0 citations

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