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Author

Esaria Oliver

2 papers indexed here

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Open access Aug 2026

Decoding neuronal vulnerability: Multidimensional analysis of D1R‐ and D2R‐ medium‐sized spiny neurons in Huntington's disease

Abstract Understanding the molecular mechanisms driving selective neuronal vulnerability to different neurodegenerative disorders remains a crucial, unsolved question. Here, we explored the case of Huntington's disease (HD), where the striatum and, specifically, dopamine receptor 1 (D1R) and dopamine receptor 2 (D2R) m...

G. Bergonzoni, Miguel Pellegrini, A. Savino et al. · 0 citations
Open access Sep 2026

Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities

Using single-nucleus RNA sequencing across 109 human and 22 mouse samples spanning dorsal and ventral striatum, a comprehensive atlas of subregional neuronal specialization is provided, suggesting divergent pharmacological targets, connectivity, and disease mechanisms.

Raleigh M. Linville, Benjamin T. James, K. Galani et al. · 2 citations · ⚡1

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