Author

E. M. El-Fakharany

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#protein folding Open access Oct 2026

New sulfonamide derivatives as HDAC inhibitors and apoptosis inducers: design, synthesis, in silico study and anticancer evaluation

The design and synthesis of new sulfonamide derivatives for potential histone deacetylase (HDAC) inhibition showed antiproliferative activity against three cancer cell lines, and this study suggests that compound 10 may serve as a lead molecule for further optimization toward new anticancer drugs.

Omkulthom M. Al Kamaly, Esamil M. El-Fakharany, Yousra A. El-Maradny et al. · RSC Advances · 0 citations

Open access Sep 2026

Synthesis and in silico studies of hexahydroacridine derivatives as potential antitumor agents

The anticancer potential of newly synthesized hexahydro-1,8-acridinedione derivatives featuring strategic structural modifications at positions 9 and 10 is evaluated, establishing compound 4d as a promising multi-target lead scaffold, warranting further optimization toward selective anticancer therapeutics.

E. El-Helw, S. Hammad, Hassan A. Khatab et al. · Scientific Reports · 0 citations

Aug 2026

Statistical optimization of extracellular antimicrobial metabolite production by Streptomyces enissocaesilis ASB isolate targeting multidrug-resistant pathogens

Findings highlight S. enissocaesilis ASB as a promising source of extracellular bioactive metabolites and provide a foundation for future studies involving compound purification, structural characterization, safety evaluation, and translational development against MDROs.

A. Badawy, E. M. El-Fakharany, Jehan S. Albrahim et al. · Biologia · 0 citations