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Open access Oct 2026

Human organ chip models recapitulate FRC-driven high endothelial venule differentiation, immune recruitment, and cancer-induced disruption.

High endothelial venules (HEVs) are specialized post-capillary venules that gate lymphocyte entry into lymph nodes, yet human in vitro models that capture their specialization remain limited. Here, we develop a perfusable human HEV-on-chip in which blood endothelial cells (BECs) form an engineered microvessel within a...

Elizabeth Oh, Esak Lee · 0 citations
Open access Aug 2026

Endothelial glycocalyx glycan expression in lymphatic vasculature in mice

Lymphatic vessels are crucial for the drainage and transport of interstitial fluids, cells, and macromolecules. Like all other cells, lymphatic endothelial cells express a cell-surface glycocalyx, composed of carbohydrate-enriched molecules, that contributes to endothelial barrier maintenance and cell-cell communicatio...

Issahy Cano, Esak Lee · 0 citations

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