Sep 2026
SuFEx Cyclization Enables DNA-Encoded Macrocyclic Peptide Libraries for Drug Discovery
Rapid, aqueous macrocyclization strategies that proceed in high conversion are valuable for ultralarge macrocyclic peptide (MP) library synthesis via display and DNA-encoded library (DEL) technology. Here we report an on-DNA macrocyclization based on sulfur(VI) fluoride exchange (SuFEx) that unites above features. Th...
Tian-Xiong Mi, Li-Jun Fan, Amber Hackler et al.
· Journal of the American Chem... · 0 citations