Author

Ernesto Anoz-Carbonell

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Open access Sep 2026

Siderophore-Enabled Delivery of Carbapenem and Metallo-β-Lactamase Inhibitor: A Promising Strategy against Multidrug-Resistant Pseudomonas aeruginosa

Carbapenem-resistant Pseudomonas aeruginosa (CRPA), a World Health Organization high-priority pathogen, represents a major clinical threat due to limited treatment options. Its intrinsic resistance is driven in part by extremely low outer-membrane permeability, which restricts antibiotic uptake, while the increasing pr...

Shahriar Safari, Ravil Petrov, Y. Ustimenko et al. · Journal of the American Chem... · 0 citations

Aug 2026

BVL3572S inhibits HisC and AlaA, exploiting vitamin B6 dependency to kill Mycobacterium tuberculosis.

These findings establish BVL3572S as a promising lead compound acting through a previously unexploited, multitarget mechanism, and display strong synergy with the antitubercular drug D-cycloserine.

Zainab Edoo, Astrid Lenne-Delmotte, C. Grosse et al. · Cell Chemical Biology · 0 citations