Eric W. Salter

Antithetical roles of tau in hippocampal long-term synaptic depression in rats versus mice

Synaptic dysfunction is a primary feature of tauopathies, a group of major neurodegenerative diseases that includes Alzheimer’s disease. However, the normal synaptic functions of tau are poorly understood. Since rats provide advantages over mice for understanding human tau, such as expressing six tau isoforms and showi...