Author

Eric S Zigon

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Open access Jul 2026

Using enantioselective biosensors to evolve asymmetric biocatalysts.

This work evolves enantioselective transcription factors that convert enzyme-catalyzed enantiomer concentrations into programmable gene expression outputs, focusing on imine reductases, and designs a genetic circuit that enables TF generation within weeks.

Simon d’Oelsnitz, Wantae Kim, Nicole N Zhao et al. · Nature Chemical Biology · 7 citations