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Author

Eric Calvo

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Open access Sep 2026

The black fly salivary protein Simukunin inhibits complement activation through the lectin pathway protease MASP-2

Salivary secretions from blood-feeding arthropods are enriched with bioactive molecules that counteract host hemostatic and immune defenses, including blood coagulation, platelet aggregation, complement activation, and vasoconstriction. Although numerous salivary components have been identified and functionally charact...

Michelle D. Jung, Molly E. Ring, Brian G. Bonilla et al. · 0 citations
Open access Sep 2026

Chromosome-Level Genome of Simulium vittatum Links Black Fly Cytogenetics to Genome Organization and Evolution

This reference genome connects classical black fly cytogenetics with sequence-level analyses of genome organization, structural variation, and gene content, addressing a major genomic gap within Culicomorpha and providing a foundation for comparative studies of chromosome evolution, hematophagy, and vector biology acro...

E. Nishiduka, Tom Hill, Stephen Lu et al. · 0 citations
Open access Jul 2026

C3 complement inhibition by Sicpin, a salivary protein from Simulium nigrimanum 2328025

It is found that Sicpin modulates the complement system, with potential implications for pathogen transmission, blood feeding, and therapeutic development, and the findings support that Sicpin modulates the complement system.

Paola Carolina Valenzuela Leon, Molly Ring, Brian Bonilla et al. · 0 citations

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