Author

Enrico Lugli

2 papers indexed here

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Open access Aug 2026

Molecular heterogeneity and clonal origin of CCR8+ effector regulatory T cells in human cancer

CD4+CD25+FOXP3+ regulatory T cells (Treg) are highly activated in tumors and promote disease progression. Specific, universal targeting of these effector Treg cells is limited by the lack of a conserved signature across human cancers and information on their origin. Here we combine analysis of single-cell RNA-sequencin...

J. Swatler, S. Puccio, Emanuele Voulaz et al. · Nature Communications · 0 citations

Sep 2026

Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species.

Reactive oxygen species (ROS) promote genomic instability and fuel oncogenic signaling in cancer, but antioxidant therapies have so far failed to improve, or worsen, cancer outcomes. Emerging data suggest that T cells depend on ROS for signal transduction. In this study, we show that tumors exploit this dependency, rel...

Alexander J. Wesolowski, Ardon M. Pillay, Panagiota Vardaka et al. · Science · 1 citation