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Author

Enric Vercher

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Open access Sep 2026

Structure-function profiling identifies determinants of TCR-T cell therapeutic efficacy

A mechanistic basis and a conceptual framework for the selection and optimization of TCRs for adoptive immunotherapy are provided for the selection and optimization of TCRs for adoptive immunotherapy.

Leire Oyon-Olea, Enric Vercher, M. G. Dichiara-Rodríguez et al. · 0 citations
Open access Sep 2026

TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment

This study provides evidence for a key role of TNFR1, as expressed by malignant cells, in orchestrating a pro-tumor immunosuppressive environment through secondary inflammatory mediators. Results highlight the relevance of interfering TNFα/TNFR1 in cancer immunotherapy.

Elixabet Bolaños, Lorena Cañas-Zabala, Irene Olivera et al. · 0 citations

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