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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Engin Demirdizen

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2 papers indexed here

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Open access Sep 2026

Uncovering pan-cancer signatures of chemoresistance

This is the first comprehensive study that redefines chemoresistance as a proliferative, MYC-driven state and uncover SRM as a tractable vulnerability, offering new avenues for therapeutic intervention across diverse epithelial malignancies.

Mohammed M. A. Inayatullah, Engin Demirdizen, Z. Keepers et al. · 0 citations
Open access Aug 2026

Targeting PRMT5 Inhibitor–Induced Adaptation in Pancreatic Cancer with the RBM39 Degrader Indisulam

Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a formidable clinical challenge. Next-generation protein arginine methyltransferase 5 (PRMT5) inhibitors show promising clinical results in a subset of PDACs with codeletion of the tumor-suppressor CDKN2A and the methylthioadenosine phosphorylase (MTAP) gene, but...

Valentina Spielmann, Jonas Buchloh, Selen Selcen et al. · 0 citations

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