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Ena S. Tully

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Open access Aug 2026

Structural and biochemical analysis of the IBV nsp15 endoribonuclease reveals the necessity of peripheral site residues for activity

Cryo-electron microscopy and biochemistry are used to characterize IBV nsp15’s interactions with RNA, demonstrating a preference for IBV nsp15 to cleave double-stranded RNA over single-stranded RNA and observing nsp15 hexamers with two double-stranded RNAs bound simultaneously.

Ena S. Tully, R. Kirchdoerfer · 0 citations

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