Open access
Aug 2026
Structural and biochemical analysis of the IBV nsp15 endoribonuclease reveals the necessity of peripheral site residues for activity
Cryo-electron microscopy and biochemistry are used to characterize IBV nsp15’s interactions with RNA, demonstrating a preference for IBV nsp15 to cleave double-stranded RNA over single-stranded RNA and observing nsp15 hexamers with two double-stranded RNAs bound simultaneously.
Ena S. Tully, R. Kirchdoerfer
· bioRxiv · 0 citations