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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Emre Karakoc

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Open access Sep 2026

Structure-function analysis of PI3K signalling cascade base editing screens in cancer cells

Large-scale CRISPR base editing mutagenesis screens across 30 PI3K pathway proteins in three disease-relevant cancer cell models establish high-throughput base editing mutagenesis combined with structural analysis as a scalable strategy to delineate structure–function relationships and inform drug development.

Katrina McCarten, Bárbara Abreu, Benoit Baillif et al. · 0 citations

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