Open access
Sep 2026
Synthesis of Antiproliferative N-Chalconyl Imidazolidones and Mechanistic Evaluation of Prototype N-CIMZ 1 as a Macrophage-Modulating Antimitotic Agent
Background/Objectives: To address current aggressive breast cancer challenges, a novel series of eight N-chalconyl imidazolidone derivatives (N-CIMZs 1–8) was synthesized and evaluated for direct cytotoxicity and immunomodulation via macrophage polarization. Methods: Following antiproliferative screening against four r...
Atziri Corin Chavez Alvarez, Lisa Treboux, Céline Audrey Béchon-Diot et al.
· Pharmaceuticals · 0 citations