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Emmanuel K. Woode

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Open access Sep 2026

Preferential engagement of the anti-inflammatory ATP/adenosine axis by HIV vaccine candidate with V1-deleted envelope in male rhesus macaques

Ex vivo, ΔV1 gp120 reduced CCR5 expression on CD4+ T cells relative to WT gp120, consistent with the anti-inflammatory mucosal response by ΔV1-vaccine regimens in vivo, promotes an anti-inflammatory mucosal landscape less permissive to HIV seeding and dissemination following virus exposure.

Isabela Silva de Castro, Mohammad Arif Rahman, Massimiliano Bissa et al. · 0 citations

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