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Emma Hilton-Balfe

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#protein folding Open access Sep 2026

Cyclic tri-adenylate controls a CARF-TM effector in type II Panoptes anti-phage systems

Cyclic nucleotide second messengers are used in all domains of life to amplify viral infection signals and activate cellular defences. In prokaryotes, CBASS (cyclic nucleotide-based antiphage signalling system) and type III CRISPR-Cas systems generate a range of cyclic nucleotides which bind and allosterically activate...

S. Grüschow, Peter Wotherspoon, Emma Hilton-Balfe et al. · 1 citation · ⚡1

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