Author

Emily R. Sartori

2 papers indexed here

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Open access Aug 2026

Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains

Summary The pathological hallmarks of neurodegeneration are the aberrant post-translational modification and aggregation of proteins. Genetic factors, like APOE4, increase the prevalence and severity of tau, amyloid, and α-synuclein pathologies. However, the human brain is largely inaccessible during this process, limi...

Louise A. Mesentier-Louro, Camille Goldman, Sebastian Gaese et al. · Cell Stem Cell · 1 citation

Open access Sep 2026

Large-scale single-molecule analysis of tau proteoforms

Proteins exist as diverse proteoforms resulting from a combination of genetic variation, alternative splicing and post-translational modifications. Current methods struggle to capture this complexity at the single-molecule level. Here we introduce Iterative Mapping of proteoforms, a method that enables massively parall...

James Joly, V. Budamagunta, Zheng-Jian Zhang et al. · Nature Methods · 1 citation