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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Emily Naylor

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Open access Aug 2026

Destabilization of intratumor Tregs by CTLA-4 engagement confers anti-CTLA-4-driven immunotherapy

It is shown that anti-CTLA-4 antibody engages CTLA-4 in Tregs specifically in the tumor tissues to reduce their stability and survival and weaken their suppressive function through upregulating TGF-β signaling, which leads to the antibody-mediated - upregulation of CD4+ and CD8+ effector T cell anti-tumor immunity and...

Na Liu, Jun-Ji Xu, Wai Lim Ku et al. · 0 citations

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