Author

Emil K. Gustavsson

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Open access Oct 2026

Neurodegenerative disease risk associated with gene expression in peripheral monocytes across ancestries

It is hypothesised that peripheral immune states responding to regional environmental triggers contribute to central neurodegeneration. Region-specific genetic selection pressures require this hypothesis to be assessed in an ancestry-specific manner. Here, we utilise genome-wide association studies and expression qua...

Aaron Z. Wagen, R. Reynolds, J. Foo et al. · Communications Biology · 0 citations

Open access Oct 2026

Protocol for genome-wide differential methylation using long-read DNA sequencing in the cortex of a mouse model of Alzheimer's disease.

Third-generation sequencing enables direct detection of genome-wide 5-methylcytosine without bisulfite conversion. Here, we present a protocol for generating long-read DNA sequencing from mouse cortex and performing genome-wide differential methylation analysis. We describe steps for high-molecular-weight DNA extractio...

U. Yaman, Emil K. Gustavsson, Jasmaine Lee et al. · STAR Protocols · 0 citations

Open access Aug 2026

SALRR: Scalable Analysis of Long-Read RNA-Seq Enables Comprehensive Transcriptome Profiling in Human Brain

An integrated wet-lab and computational platform designed to overcome barriers to population-scale long-read RNA sequencing, providing a scalable, community-ready framework for isoform-resolved transcriptomics in neurodegeneration, aging, and complex brain disease.

C. Kouam, Jackson Mingle, Pilar Álvarez Jerez et al. · bioRxiv · 0 citations