Emanuele Colombo

Inflammatory macrophages promote metastatic potential in Triple-negative Breast Cancer through Integrated Stress Response signaling

Triple-negative Breast Cancer (TNBC) is characterized by inflammatory myeloid infiltration and a high metastatic potential, however, the mechanisms by which macrophage-derived signals govern tumor cell plasticity remain poorly understood. Here, through patient transcriptomic analyses, in vitro functional studies, and...