Eman Z. El Razaz

Design, synthesis, structure-activity relationship and in-silico studies of novel pyrazolo[1,5-a]pyrimidine derivatives as selective COX-2 inhibitors with promising anti-inflammatory activity and safety profile.

A novel series of pyrazolo[1,5-a]pyrimidine derivatives was designed using ligand-based pharmacophore modeling, and their structures were confirmed by 1H/13C NMR and LC-MS, establishing 8a and 8i as potent, selective, and structurally stable lead candidates for preclinical COX-2 inhibitor development.