Open access
Jul 2026
Single-cell-derived ferroptosis signature predicts prognosis and therapy response in esophageal squamous cell carcinoma
A single-cell-resolved ferroptosis gene signature with strong prognostic and therapeutic implications for ESCC is presented, showing that knockdown of CDCA3 lead to the downregulation of ferroptosis inhibitor-related genes and upregulation of ferroptosis-promoting genes, thereby enhancing the sensitivity to RSL3-induced ferroptosis.
Qing Xu, Yu Ma, Xuanqi Huang et al.
· Frontiers in Oncology · 0 citations